The Neuromuscular Junction and Botulinum Toxin Type A
نویسندگان
چکیده
منابع مشابه
Comparison of the action of types A and F botulinum toxin at the rat neuromuscular junction.
Blockade of neuromuscular transmission was produced in the lower hind limb of the rat by local injection of either type A or type F botulinum toxin (BoTx). At 1, 3, 7, and 10 days after injection, the extensor digitorum longus (edl) nerve-muscle preparation was excised and analyzed for alterations in muscle mechanical properties or spontaneous and nerve stimulus-evoked quantal transmitter relea...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Characterization of a vertebrate neuromuscular junction that demonstrates selective resistance to botulinum toxin.
Botulinum toxin blocks transmitter release by proceeding through a series of four steps: binding to cell surface receptors, penetration of the cell membrane by receptor-mediated endocytosis, penetration of the endosome membrane by pH-induced translocation, and intracellular proteolysis of substrates that govern exocytosis. Each of these steps is essential for toxin action on intact cells. There...
متن کاملproduction and crystallization of clostridium botulinum type a toxin
introduction: widespread medical usage of botulinum toxins has increased the need for the precise analysis of its biological activity. the aim of this study was production and crystallization of the botulinum type a toxins. methods: in this study, clostridium botulinum was grown and inoculated into the tripticase soya broth culture media, under anaerobic condition and toxin production was monit...
متن کاملBotulinum toxin type B for dynamic glabellar rhytides refractory to botulinum toxin type A.
BACKGROUND Botulinum toxin type B (BTX-B; Myobloc) has recently been introduced for the treatment of dynamic rhytides. This serotype is structurally similar to botulinum toxin type A (BTX-A; Botox) and appears to produce equivalent muscular paralysis. Because of the fact that some patients may become resistant to the effects of BTX-A with its continued use or may require large doses of type A t...
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ژورنال
عنوان ژورنال: The Japanese Journal of Rehabilitation Medicine
سال: 2013
ISSN: 1881-3526,1881-8560
DOI: 10.2490/jjrmc.50.298